In vivo monitoring of skeletal aluminum burden in patients with renal failure

K. Ellis; S. Kelleher; A. Raciti; J. Savory; M. Wills

doi:10.1007/bf02035508

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 124: Issue 1

In vivo monitoring of skeletal aluminum burden in patients with renal failure

Authors:

K. Ellis

K. Ellis Brookhaven National Laboratory Medical Department 11973 Upton New York (USA)

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S. Kelleher

S. Kelleher SUNY-Stony Brook Health Science Center 11794 Stony Brook New York (USA)

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A. Raciti

A. Raciti SUNY-Stony Brook Health Science Center 11794 Stony Brook New York (USA)

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J. Savory

J. Savory University of Virginia Medical School 22908 Charlottesville Virginia (USA)

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M. Wills

M. Wills University of Virginia Medical School 22908 Charlottesville Virginia (USA)

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Pages:: 85–95

Online Publication Date:: 13 Aug 2005

Publication Date:: 17 Sep 1988

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02035508

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Abstract

In vivo neutron activation analysis was used to examine the total body and partial body (hand) aluminum levels in patients with end-stage renal failure. Patients maintained on chronic hemodialysis had higher mean body burdens of aluminum than, did those clinically managed without dialysis. Approximately 70% of the patients examined indicated elevated levels of body or skeletal aluminum. A significant correlation was observed between the in vivo aluminum/calcium ratio obtained for the hand measurement and the increase in serum aluminum levels following a disferroxamine infusion test. The direct in vivo monitoring of hand Al/Ca values in patients may provide an alternate choice to bone biopsy for the detection of aluminum intoxication.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)