Characterization of C-11-SCH 23390 and its possible metabolites in primate blood using high performance liquid chromatography

O. De Jesus; M. Tokars; G. Van Moffaert; Y. Chen; W. Woolverton; M. Cooper

doi:10.1007/bf02041750

Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 125: Issue 1

Characterization of C-11-SCH 23390 and its possible metabolites in primate blood using high performance liquid chromatography

Authors:

O. De Jesus

O. De Jesus

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M. Tokars

M. Tokars Franklin McLean Research Institute The University of Chicago Positron Emission Tomography Center 5841 South Maryland Avenue 60637 Chicago IL (USA)

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G. Van Moffaert

G. Van Moffaert Franklin McLean Research Institute The University of Chicago Positron Emission Tomography Center 5841 South Maryland Avenue 60637 Chicago IL (USA)

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Y. Chen

Y. Chen Franklin McLean Research Institute The University of Chicago Positron Emission Tomography Center 5841 South Maryland Avenue 60637 Chicago IL (USA)

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W. Woolverton

W. Woolverton The University of Chicago Department of Pharmacological and Physiological Sciences 5841 South Maryland Avenue 60637 Chicago IL (USA)

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M. Cooper

M. Cooper Franklin McLean Research Institute The University of Chicago Positron Emission Tomography Center 5841 South Maryland Avenue 60637 Chicago IL (USA)

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Pages:: 65–74

Online Publication Date:: 13 Aug 2005

Publication Date:: 17 Nov 1988

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02041750

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Abstract

A selective dopamine D1 antagonist, SCH 23390, is routinely labelled with C-11 at our institution for use in imaging dopamine D1 receptors in primate brain using positron emission tomography.However, little is known about the metabolism of this compound. In this report, a method is presented for the HPLC characterization of SCH 23390 and its possible metabolites in blood using a liquid-solid extraction technique. This procedure was applied to the analysis of blood samples collected at time intervals from rhesus monkeys after the injection of C-11-SCH 23390. About 4 minutes after injection, polar metabolite(s) were found in the circulation. However, the amounts detected would not be expected to interfere with the analysis of brain PET scans.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)