Technetium-99m-diethyl-IDA instant kit: Labelling kinetics and biological properties

N. Agha; K. Nashat; N. Yousif

doi:10.1007/bf02278271

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 134: Issue 2

Technetium-99m-diethyl-IDA instant kit: Labelling kinetics and biological properties

Authors:

N. Agha

N. Agha Nuclear Research Centre Radioisotope Production Department P.O. Box 765 Baghdad (Iraq)

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K. Nashat

K. Nashat Nuclear Research Centre Radioisotope Production Department P.O. Box 765 Baghdad (Iraq)

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N. Yousif

N. Yousif Nuclear Research Centre Radioisotope Production Department P.O. Box 765 Baghdad (Iraq)

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Pages:: 333–341

Online Publication Date:: 10 Dec 2005

Publication Date:: 17 Dec 1989

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02278271

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Abstract

A formulation of stannous-diethyl-IDA freeze-dried kit, containing 50 mg diethyl-IDA and 0.4 mg hydrated stannous chloride, to be labelled with technetium has been developed for hepatobiliary scintigraphy. Gel chromatography column scanning technique has been applied for determination of technetium fractions in the preapration. The optimal pH value of the preparation with a high hepatobiliary specificity was found between 5.5 to 6.0. Effect of ligand to metal ratio on the stability of the prepared Sn-diethyl-IDA solution prior mixing with technetium has been investigated. The reaction conditions (initial pH) between the ligand and stannous ion affects the percent hydrolysis of the labelled compund, i.e. the formation rate of the complex. The organ distribution data of^99mTc-diethyl-IDA in mice for 60 minutes post injection were satisfactory. The radiopharmaceutical exhibits rapid blood clearance, great hepatic clearance and very short hepatocyte transit time. Uptake of the radiopharmaceutical in various organs of mouse at 5 minute post injection showed that the greater part of the injected radioactivity has distributed between liver and intestine. However, about 12% and 60% of the injected dose has been found in liver and intestine respectively. The renal uptake of the HB agent in mice is relatively low and decreases with time to become about 0.3% at 60 minutes post injection. Blood clearance data of the radiopharmaceutical kit in rabbits showed that the HB agent is-rapidly cleared, since the initial decrease was very fast with a half-time of 1.5 minutes.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)