Synthesis of N-isopropyl-p-123I-amphetamine and biodistribution in rats

M. Figols; R. Gonçalves; E. Muramoto; S. Sato; D. Freire Martinez; M. Colturato; C. Gonçalves; J. Knust

doi:10.1007/bf02164725

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 136: Issue 5

Synthesis of N-isopropyl-p-¹²³I-amphetamine and biodistribution in rats

Authors:

M. Figols

M. Figols /IPEN/, CNEN/SP Instituto de Pesquisas Energéticas e Nucleares São Paulo Brazil

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R. Gonçalves

R. Gonçalves /IPEN/, CNEN/SP Instituto de Pesquisas Energéticas e Nucleares São Paulo Brazil

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E. Muramoto

E. Muramoto /IPEN/, CNEN/SP Instituto de Pesquisas Energéticas e Nucleares São Paulo Brazil

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S. Sato

S. Sato /IPEN/, CNEN/SP Instituto de Pesquisas Energéticas e Nucleares São Paulo Brazil

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D. Freire Martinez

D. Freire Martinez Dirección General de Energia Nuclear Guatemala

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M. Colturato

M. Colturato /IPEN/, CNEN/SP Instituto de Pesquisas Energéticas e Nucleares São Paulo Brazil

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C. Gonçalves

C. Gonçalves /IPEN/, CNEN/SP Instituto de Pesquisas Energéticas e Nucleares São Paulo Brazil

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J. Knust

J. Knust Universitätsklinikum Radiologisches Zentrum D-4300 Essen FRG

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Pages:: 331–339

Online Publication Date:: 27 Sep 2005

Publication Date:: 17 Jul 1989

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02164725

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Abstract

The described labelling and purification preparation of N-isopropyl-p-¹³¹I-amphetamine /¹³¹I-IMP/ represents a fast and efficient method to obtain a compound that fulfils all criteria of purity for its in-vivo application. After isotope exchange and quality control¹³¹I-IMP could be obtained with radiochemical yields in the range between 68% and 78% with a radiochemical purity of 98–99%. As demonstrated in animal experiments the cerebral affinity of IMP offers a possibility for the diagnosis of brain diseases in clinical studies when the product is labelled with¹²³I.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)