Authors:
A. Jabbar Nuclear Research Centre Radioisotope Production Department Tuwaitha Baghdad (Iraq)

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H. Karim Nuclear Research Centre Radioisotope Production Department Tuwaitha Baghdad (Iraq)

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M. Al-Janabi Nuclear Research Centre Radioisotope Production Department Tuwaitha Baghdad (Iraq)

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Abstract  

Sn-alanine kits were prepared in lyophilized form containing 7.02·10–2 M -alanine and 5.5·10–4M stannous chloride dihydrate. The optimal pH value of the preparation was found to be equal to 4.3–5.1. The radiochemical purity and the stability of99mTc-alanine were assessed by gel filtration column scanning techniques (GCS) and thin layer chromatography, and the labelling yield of the complex was higher than 95%. The organ distribution data in mice showed that more than 90% of the injected dose had been accumulated in the liver. However, a negligible amount of radioactivity was detected in the non-target organs. The stability of99mTc-alanine was followed for 5 hours and the Sn-alanine kit was stable for at least 3 months.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)