Fission neutron spectrum averaged cross-sections were measured for the reactions64Zn(n, p)64Cu,67Zn(n, p)67Cu and68Zn(n, )65Ni by the activation technique, using radiochemical separations and -spectroscopy. The preparation of64Cu and67Cu in a nuclear reactor was studied. The64, 67Cu was separated from zinc matrix activity using anion exchange column technique.