Comparative evaluation of four different99mTc-sulfur colloid kits used for liver scanning

Y. Shafiq; M. Al-Hissoni; M. Abdel-Azeez; M. Jassm; A. Al-Hilli

doi:10.1007/bf02060555

Jump to Content

Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 148: Issue 1

Comparative evaluation of four different^99mTc-sulfur colloid kits used for liver scanning

Authors:

Y. Shafiq

Y. Shafiq Nuclear Research Centre Radioisotope Production Department P.O. Box 765 Baghdad (Iraq)

Search for other papers by Y. Shafiq in
Current site
Google Scholar
PubMed

M. Al-Hissoni

M. Al-Hissoni Ibin Al-Nafees Hospital for Cardiovascular Diseases Department of Nuclear Medicine Baghdad (Iraq)

Search for other papers by M. Al-Hissoni in
Current site
Google Scholar
PubMed

M. Abdel-Azeez

M. Abdel-Azeez Nuclear Research Centre Radioisotope Production Department P.O. Box 765 Baghdad (Iraq)

Search for other papers by M. Abdel-Azeez in
Current site
Google Scholar
PubMed

M. Jassm

M. Jassm Ibin Al-Nafees Hospital for Cardiovascular Diseases Department of Nuclear Medicine Baghdad (Iraq)

Search for other papers by M. Jassm in
Current site
Google Scholar
PubMed

, and

A. Al-Hilli

A. Al-Hilli Nuclear Research Centre Radioisotope Production Department P.O. Box 765 Baghdad (Iraq)

Search for other papers by A. Al-Hilli in
Current site
Google Scholar
PubMed

View More View Less

Pages:: 133–143

Online Publication Date:: 14 Aug 2005

Publication Date:: 17 Mar 1991

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02060555

Restricted access

Abstract

The distribution of four different commercially available A, B, C, D kits (^99mTc-sulfur colloid) for hepatoimaging was compared in mice by organ radioassay and in rabbits for blood clearance. The distribution of kits A and C (single step kits) was assessed in the human by blood clearance, external liver, spleen measurement, and scintillation camera imaging. Kit A reaches a high concentration in liver within 15–20 minutes with relatively high surrounding tissue background, and superior spleen scintiphotos. However, when kit C was used, a high activity concentration in the liver was reached within 10–15 minutes with low tissue background and faint visualization of the radiotracer in the spleen. Blood clearance of the four^99mTc-sulfur colloids was determined in rabbits. The data obtained indicated that the four hepatoagents exhibit rapid blood clearance but the initial decrease of blood activity curve of kit D was relatively faster than the other three hepatic agents. The biodistribution is similar for the four^99mTc-S-colloids but the blood retained higher activity residue using kit A compared with others. The formation of^99mTc-sulfur colloid using kits B, D (multistep kits) involves many steps after the addition of^99mTcO ₄^– to the reagent. These procedures are time consuming, required facilities at the medical institutions and give rise to the radiation exposure. While single step kits A and C have the same diagnostic value, the use of kit C allows a reduction of absorbed radiation, which may be useful in the liver exploration in children.

Save
Cite
Email this content

Share Link

Copy this link, or click below to email it to a friend
Email this content
or copy the link directly:

https://akjournals.com/abstract/journals/10967/148/1/article-p133.xml
The link was not copied. Your current browser may not support copying via this button.

Link copied successfully

Collapse
Expand

Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)