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  • 1 Bhabha Atomic Research Centre Chemistry Division Trombay 400 085 Bombay India
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Abstract  

The use of beams of heavy ions such as carbon, neon and argon for radiation therapy has the advantage that they have a very sharp Bragg maximum. When the Bragg peak coincide with the tumour location, it is possible to deposit the bulk of the energy of the ion in the region occupied by the malignancy. However, the concentration of ions and free radicals will be very high in the Bragg peak region which has not received the attention it deserves. So mutual recombination of these species will be very high. It is therefore necessary to assess the extent of these radical-radical recombinations at very high LET values. Spur diffusion model calculations have been made for high energy argon ions using water as a medium. For comparison, calculations have been done for proton tracks. It has been shown that in the Bragg peak region of argon ions even very high concentrations of scavengers have very little effect on radical-radical interactions. The implication is that when LET values are very high, practically all the radicals undegro recombination with each other. In order to explain the observed lethality of high LET radiation, it is suggested that the hydrogen peroxide formed also contribute to the killing of cells. In addition, the decomposition of H2O2 will contribute oxygen. This may be one of the reasons why high LET radiation shows strong lethality to hypoxic cells.

Manuscript Submission: HERE

  • Impact Factor (2019): 1.137
  • Scimago Journal Rank (2019): 0.360
  • SJR Hirsch-Index (2019): 65
  • SJR Quartile Score (2019): Q3 Analytical Chemistry
  • SJR Quartile Score (2019): Q3 Health, Toxicology and Mutagenesis
  • SJR Quartile Score (2019): Q2 Nuclear Energy and Engineering
  • SJR Quartile Score (2019): Q3 Pollution
  • SJR Quartile Score (2019): Q3 Public Health, Environmental and Occupational Health
  • SJR Quartile Score (2019): Q3 Radiology, Nuclear Medicine and Imaging
  • SJR Quartile Score (2019): Q3 Spectroscopy
  • Impact Factor (2018): 1.186
  • Scimago Journal Rank (2018): 0.408
  • SJR Hirsch-Index (2018): 60
  • SJR Quartile Score (2018): Q2 Nuclear Energy and Engineering
  • SJR Quartile Score (2018): Q2 Pollution

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
4
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)