Preliminary study of trace elements in human brain tumor tissues by instrumental neutron activation analysis

Zhuang Guisun; Wang Yinson; Tan Mingguang; Zhi Min; Wang Yongjie; Zhang Fulin

doi:10.1007/bf02035492

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 151: Issue 2

Preliminary study of trace elements in human brain tumor tissues by instrumental neutron activation analysis

Authors:

Zhuang Guisun

Zhuang Guisun Shanghai Institute of Nuclear Research Academia Sinica P.O. Box 800-204 201 800 Shanghai (P.R. China)

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Wang Yinson

Wang Yinson Shanghai Institute of Nuclear Research Academia Sinica P.O. Box 800-204 201 800 Shanghai (P.R. China)

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Tan Mingguang

Tan Mingguang Shanghai Institute of Nuclear Research Academia Sinica P.O. Box 800-204 201 800 Shanghai (P.R. China)

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Zhi Min

Zhi Min Shanghai Institute of Nuclear Research Academia Sinica P.O. Box 800-204 201 800 Shanghai (P.R. China)

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Wang Yongjie

Wang Yongjie Shanghai Institute of Nuclear Research Academia Sinica P.O. Box 800-204 201 800 Shanghai (P.R. China)

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Zhang Fulin

Zhang Fulin Hua Shan Hospital Department of Pathology and Neurology Shanghai (P. R. China)

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Pages:: 327–335

Online Publication Date:: 13 Aug 2005

Publication Date:: 17 Oct 1991

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02035492

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Abstract

Elemental profiles of brain tumor tissues from 15 patients of astrocytomas (grade I–III) and normal human brain tissues of 23 male age matched autopsies as controls have been studied by instrumental neutron activation analysis. The SLOWPOKE reactor with a thermal neutron flux of 8·10¹¹n·cm^–2·s^–1 and swimming pool type reactor with a thermal neutron flux of 1·10¹³n·cm^–2·s^–1 were used for short and long irradiation of samples, respectively. Spectrophotometry was only used for analyzing phosphorus. A total of 18 elements Se, Na, K, Br, Cl, Mn, Mg, S, Ca, Cu, Hg, Cr, Fe, Rb, Zn, Co, Sc and P has been determined for this purpose. The reliability of methods has been checked by analyzing biological standard reference materials horse kidney (IAEA H-8) and bovine liver (NBS SRM 1577a). The analytical results showed that compared with the normal brain tissues, concentrations of Ca, Fe, Cu, Zn, Se, Mn, Br and Sc were significantly higher in tumor tissues (P<0.01) and concentrations of Rb, K and P were lower, while no differences for contents of Mg, S, Cr, Hg, Na and Cl were observed. A negative correlation between P and Ca in malignant and normal brain tissues was observed.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)