Authors:
E. Sabbioni JRC-Ispra Site CEC, Environment Institute 21020 Ispra, Varese (Italy)

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M. Bonardi University and INFN Accelerator and Applied Superconductivity Laboratory, LASA Via F. lli Cervi 201 20090 Segrate, Milano (Italy)

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M. Gallorini CRAA, CNR Pavia (Italy)

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R. Pietra JRC-Ispra Site CEC, Environment Institute 21020 Ispra, Varese (Italy)

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S. Fortaner JRC-Ispra Site CEC, Environment Institute 21020 Ispra, Varese (Italy)

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G. Tartaglia JRC Petten Establishment CEC, Institute for Advanced Materials 1755 ZG Petten (The Netherlands)

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F. Groppi University and INFN Accelerator and Applied Superconductivity Laboratory, LASA Via F. lli Cervi 201 20090 Segrate, Milano (Italy)

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Abstract  

The use of radiotracers with high specific activity in research on health impact of trace metals overcomes many of the analytical difficulties associated with experimentation carried out at metal levels which are typical of the polluted environment. It allows one to detect and measure ultratrace amounts of metals in biological samples and to follow them into different biochemical compartments, such as subcellular fractions and molecular components. This work shows typical examples of metallotoxicological studies carried out at the JRC-Ispra using radioisotopes with high specific radiactivity produced in the nuclear reactor and in the cyclotron. Applications refer to the use of45Ti,48V,64Cu,95Nb and106mAg in in-vivo and in-vitro studies related to environmental and occupational toxicology research on trace metals.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)