An optimal software and information system for NAA techniques has been developed. The system includes a data base and software complex. A number of original analog simulation algorithms of the gamma-spectrum of an activated sample were tested. The calculations of the metrological characteristics of optimal AA conditions were used as a basis. The analog simulation program for activation in a reactor, neutron generator, or with a252Cf radiation source simulates the -spectrum of a sample taking into account the decay chains up to the 15th link. A research of the optimal activation conditions for the determination of elements is conducted within a wide range of variations using the data base management system.