Activation analysis in a multitechnique study of trace element imbalances in age-related neurological diseases

W. Ehmann; X. Ding; S. Khare; M. Lovell; B. Ni; L. Tandon; D. Vance; D. Wenstrup

doi:10.1007/bf02040894

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 168: Issue 1

Activation analysis in a multitechnique study of trace element imbalances in age-related neurological diseases

Authors:

W. Ehmann

W. Ehmann University of Kentucky Department of Chemistry and Sanders-Brown Center on Aging 40506-0055 Lexington KY USA

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X. Ding

X. Ding University of Kentucky Department of Chemistry and Sanders-Brown Center on Aging 40506-0055 Lexington KY USA

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S. Khare

S. Khare University of Kentucky Department of Chemistry and Sanders-Brown Center on Aging 40506-0055 Lexington KY USA

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M. Lovell

M. Lovell University of Kentucky Department of Chemistry and Sanders-Brown Center on Aging 40506-0055 Lexington KY USA

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B. Ni

B. Ni University of Kentucky Department of Chemistry and Sanders-Brown Center on Aging 40506-0055 Lexington KY USA

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L. Tandon

L. Tandon University of Kentucky Department of Chemistry and Sanders-Brown Center on Aging 40506-0055 Lexington KY USA

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D. Vance

D. Vance University of Kentucky Department of Chemistry and Sanders-Brown Center on Aging 40506-0055 Lexington KY USA

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D. Wenstrup

D. Wenstrup University of Kentucky Department of Chemistry and Sanders-Brown Center on Aging 40506-0055 Lexington KY USA

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Pages:: 223–231

Online Publication Date:: 13 Aug 2005

Publication Date:: 01 Feb 1993

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02040894

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Abstract

It has been suggested that several age-related neurological diseases such as Alzheimer's disease and amyotrophic lateral sclerosis may be related to environmental toxins. Bulk sample multielement analyses by INAA alone are not adequate to define the role of trace elements in these diseases. A multitechnique approach has been developed that incorporates 14 MeV, instrumental reactor, radiochemical, and pre-irradiation chemical neutron activation analysis, together with laser microprobe mass spectrometry. The analytical scheme is able to provide bulk or protein normalized elemental concentrations, as well as microstructural, cellular, and subcellular localization information.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)