Authors:
M. Al-Kolaly Atomic Energy Authority Radioisotope Production and Labelled Compounds Department, Nuclear Research Centre Cairo Egypt

Search for other papers by M. Al-Kolaly in
Current site
Google Scholar
PubMed
Close
,
S. El-Bayoumy Atomic Energy Authority Radioisotope Production and Labelled Compounds Department, Nuclear Research Centre Cairo Egypt

Search for other papers by S. El-Bayoumy in
Current site
Google Scholar
PubMed
Close
,
M. Raieh Atomic Energy Authority Radioisotope Production and Labelled Compounds Department, Nuclear Research Centre Cairo Egypt

Search for other papers by M. Raieh in
Current site
Google Scholar
PubMed
Close
, and
A. El-Mohty Atomic Energy Authority Radioisotope Production and Labelled Compounds Department, Nuclear Research Centre Cairo Egypt

Search for other papers by A. El-Mohty in
Current site
Google Scholar
PubMed
Close
Restricted access

Abstract  

A study on the labeling of hippuran with no-carrier-added131I assisted by Cu(I) and excess of ascorbic acid is described. The role of ascorbic acid is to prevent the oxidation of Cu(I) to Cu(II) which activates the hydrolysis of o-iodohippuric acid to o-iodobenzoic acid. The use of Cu(I) allows an almost quantitative (97–99%) labeling yield to be obtained within 10–15 minutes at 100°C. The reaction is assumed to take place via the formation of an organocopper complex favoring the exchange reaction between radioiodine and inactive iodine in the hippuran molecule. The activation energy of the reaction was calculated to beE=12.2 kcal/mol.

  • Collapse
  • Expand

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)