Authors:
M. Cantone Dipartimento di Fisica dell'Università di Milano, and I.N.F.N. Sezione di Milano Milano (Italy)

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D. De Bartolo Dipartimento di Fisica dell'Università di Milano, and I.N.F.N. Sezione di Milano Milano (Italy)

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A. Giussani Dipartimento di Fisica dell'Università di Milano, and I.N.F.N. Sezione di Milano Milano (Italy)

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N. Molho Dipartimento di Fisica dell'Università di Milano, and I.N.F.N. Sezione di Milano Milano (Italy)

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L. Pirola Dipartimento di Fisica dell'Università di Milano, and I.N.F.N. Sezione di Milano Milano (Italy)

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G. Gambarini Dipartimento di Fisica del Politecnico di Milano, and I.N.F.N. Sezione di Milano Milano (Italy)

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Ch. Hansen GSF-Forschungszentrum für Umwelt und Gesundheit Institut für Biophysikalische Strahlenforschung Frankfurt am Main (Germany)

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P. Roth GSF-Forschungszentrum für Umwelt und Gesundheit Institut für Biophysikalische Strahlenforschung Frankfurt am Main (Germany)

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E. Werner GSF-Forschungszentrum für Umwelt und Gesundheit Institut für Biophysikalische Strahlenforschung Frankfurt am Main (Germany)

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Abstract  

The feasibility of ruthenium metabolism studies by stable tracer administration, with a methodology based on proton nuclear activation, is presented. In order to test that the amount of stable tracer administered does not perturb significantly the mechanism investigated, a series of comparative experiments with administration of both radioactive and stable tracers has been performed on animals. As the most critical pathway seems to be the intravenous injection, four male rabbits were given an intravenous injection of radioactive106Ru. Successively, the rabbits were given either a further injection of radioactive106Ru or injection of different quantities of natural Ru. The activity of106Ru and the concentration of natural Ru were measured in plasma samples withdrawn at different time intervals from the injections and the results were compared. Some biokinetic parameters and tissue distribution of Ru in rabbits were determined.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)