The centification of standard reference materials is of fundamental importance for environmental scientists to proceed with their own quality control programs or calibration procedures. As part of the National Institute of Standard and Technology (NIST) program, we participated in the certification of a hazardous waste material. Our efforts concentrated on judiciously using thermal and epithermal neutron activation analysis in conjunction with Compton suppression techniques. We have demonstrated that besides lowering the detection limit for several elements usually not reported by conventional NAA, Compton suppression is ideally suited to substantially reduce certain spectrla interferences. A detailed comprehensive study was undertaken using this method to highlight which isotopes can be most favorably used.