186Re/188Re labeled polypeptide microspheres as a potential radiation synovectomy agent

W. Jia; G. Ehrhardt; K. Zinn; N. Wang; A. Ketring

doi:10.1007/bf02040047

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 206: Issue 1

¹⁸⁶Re/¹⁸⁸Re labeled polypeptide microspheres as a potential radiation synovectomy agent

Authors:

W. Jia

W. Jia University of Missouri Research Reactor 65211 Columbia MO (USA)

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G. Ehrhardt

G. Ehrhardt University of Missouri Research Reactor 65211 Columbia MO (USA)

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K. Zinn

K. Zinn University of Missouri Research Reactor 65211 Columbia MO (USA)

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N. Wang

N. Wang University of Missouri Research Reactor 65211 Columbia MO (USA)

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, and

A. Ketring

A. Ketring University of Missouri Research Reactor 65211 Columbia MO (USA)

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Pages:: 107–117

Online Publication Date:: 13 Aug 2005

Publication Date:: 17 May 1996

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02040047

Keywords:: Radiation Synovectomy; Polypeptide Microspheres; Re-186; Re-188; Rheumatoid Arthritis

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Abstract

Polypeptide microspheres containing polycysteine crosslinked with polylysine were prepared and radiolabeled with¹⁸⁶Re and¹⁸⁸Re. High labeling yields with the microspheres with both¹⁸⁶Re and¹⁸⁸Re (97%) were obtained, and above 99% retention of radiolabels in water in 24 hours was obtained. Rhenum-186 labeled polycysteine and polylysine microspheres (11 ratio, 20 m as mean diameter) were injected intra-articularly into the rear stifes (knee joints) of normal New Zealand white rabbits. About 87% of injected dose was retained in rabbit stifles and adjacent tissues in 96 hours after injection, while most of the activity lost from the joints was excreted in the urine. Due to its simplicity of preparation and radiolabeling, versatility, and biodegradability, this type of conjugate system may become the therapeutics of choice for radiation synovectomy.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)