Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 206: Issue 1
Simple and efficient synthesis method of radioiodine-phenyl-pentadecanoic acid and uptake of tissues of animals
Authors:
Cheng Guang Academia Sinica Institute of Nuclear Research P.O. Box 800-204 201800 Shanghai (P.R. China)

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Zhao Jiaodong Academia Sinica Institute of Nuclear Research P.O. Box 800-204 201800 Shanghai (P.R. China)

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Zhang Jiong Academia Sinica Institute of Nuclear Research P.O. Box 800-204 201800 Shanghai (P.R. China)

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Pages:
165–169
Online Publication Date:
13 Aug 2005
Publication Date:
17 May 1996
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf02040054
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Abstract  

Fatty acid are the major energy source for the myocardium, thus radiolabeled fatty have often employed as heart imaging agent to localize ischemia and as potential probes of myocardial metabolism. This paper presents the synthesis of phenyl-pentadecanoic acid (PPA) by alkylation reaction and Wollf-Kishner method. Finally, PPA was iodinated with thallium trifluoroacetate on localizing para-position of phenyl ring and radioiodine was exchanged. The overall chemical yield was 20%, labelling yield 95%, radiochemical purity 98%. Tissues distribution of mice shows that IPPA was very high activity in mice heart muscle. Autoradiogram of mouse section at 2 min is clear.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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