For recent years, the labeling and application of Somatostatin and Its Analogues have been becoming more and more important in the both diagnosis and treatment of a variety of tumors, especially the neuroendocrine tumors. This paper's goals are to deal with the chemical aspects of the radiolabeling of somatostatin and its analogues. It reviews the selected radionuclides and bifunctional chelating agents may be used in the labeling of Somatostatin and its analogues with metal radionuclides. The prospects of application of the Labelled Somatostatin and its analogues are comparatively assessed.