Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 206: Issue 1
Radiometal (169Yb) uptake in normal and tumour cells in vitro: Influence of metabolic cell activity and complex structure
Authors:
W. Franke Dresden University of Technology Clinic and Polyclinic of Nuclear Medicine Fetscherstr. 74 D-01307 Dresden (Germany)

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G. Kampf Dresden University of Technology Clinic and Polyclinic of Nuclear Medicine Fetscherstr. 74 D-01307 Dresden (Germany)

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Pages:
29–36
Online Publication Date:
13 Aug 2005
Publication Date:
17 May 1996
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf02040038
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Abstract  

Trivalent radiometal tracers have been used for tumour imaging and metastatic pain palliation. For better understanding their tumour accumulation, basic model studies of uptake of different169Yb complexes into cultured normal and tumour cells were performed.Whereas the uptake of169Yb citrate is strongly dependent on the metabolic activity and is not tumour-cell specific, the uptake of169Yb complexed with aminocarbonic acids (NTA, EDTA, DTPA) does not correlate to the metabolic activities. These complexes are taken up to a greater amount by the tumour cells (by a factor of about 2).Uptake of both complex types leads to a stable association to cellular compounds,169Yb is not releasable by the strong complexing agent DTPA.Protein binding of the169Yb complexes shows great influence on their cellular uptake. The bound proportion is no more available for cellular uptake.The results indicate that i) uptake of169Yb citrate is an active cellular transport process which is not tumour-specific, ii) the169Yb aminocarbonic acid complexes show a weak favouring by the tumour cells, iii) different from earlier acceptions the Yb complexes studied are not taken up by the cells in protein-bound form. The structure of the Yb complex is decisive for its protein binding and cellular uptake.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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