Authors:
K. Park Korea Atomic Energy Research Institute Yuseong P. O. Box 105 Taejon (Republic of Korea)

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J. Kim Korea Atomic Energy Research Institute Yuseong P. O. Box 105 Taejon (Republic of Korea)

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R. Lambrecht Australia Nuclear Science and Technology Organization 2234 Lucas Heights (Australia)

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Abstract  

New165Dy and166Ho macroaggregates(165Dy-MA,166Ho-MA) were prepared by reacting the aqueous solution of165Dy(NO3)3 and166Ho(NO3)3, respectively, with sodium borohydride solution in 0.2N NaOH.165Dy-MA and166Ho-MA are sterile suspension of macroaggregates consisted of Dy/Ho (50–56 wt.%) and boron (5–7%) in saline with mean particle size of 2.6 m (1–8 m range). Both MA could be prepared from the pre-made164Dy-MA and165Ho-MA followed by neutron irradiation. Even though the165Dy-MA and166Ho-MA suspension in saline were stored at 37°C for 24 hrs (Dy-MA), 10 days (Ho-MA) or autoclaved at 121°C for 30 minutes, there was no significant change in particle size and no leakage problem indicating the prepared165Dy-MA and166Ho-MA are sufficiently stable. The results of in-vivo retention studies using rabbits showed high retention (>99.5%) in knee joint even at 24 hrs (165Dy-MA) or at 10 days (166Ho-MA) after administration. Rabbits treated with intra-articular injections of164Dy-MA or165Ho-MA equivalent to 20–30 times the typical clinical dose showed no signs of any toxic effects at 1 month after administration. The ease with which the165Dy-MA and166Ho-MA can be made in the narrow size range and their high in-vitro and in-vivo stability make them attractive agents for radiation synovectomy.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)