Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 206: Issue 1
New BATO complexes for brain and myocardial imaging
Authors:
Li Hongfeng Normal University Chemistry Department P.O. Box 19 100875 Beijing (P.R. China)

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Liu Boli Normal University Chemistry Department P.O. Box 19 100875 Beijing (P.R. China)

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Pages:
51–58
Online Publication Date:
13 Aug 2005
Publication Date:
17 May 1996
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf02040041
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Abstract  

Two new BATO complexes99mTcC1 (dmg)3BC6H4CH3 (Cholor[bis {2,3-butanedionedioxime(1-)-O} {2,3-butanedionedioximato (2-)-N,N',N",N'",N"",N""'} (m-tolueneborato) technetium]) and99m TcCl (4-MCDO)3MeB, ([bis{4-methyl-1,2-cyclohexanedioximato (1-)-O} {4-methyl-cyclohexane-1, 2-dione-dioximato (2-)-O} {methyl-borato (2-)-N,N', N", N'", N"", N""'} chlorotechnetium]), generally called BATO (Boronic Acid Adducts of Technetium Dioximes, had been synthesized and evaluated for potential use in brain and myocardial perfusion imaging. Their labeling conditions were also investigated. In their biodistribution studyies they showed higher radiochemical stability and rapid brain uptake and myocardial uptake in mice. After i.v administration, the first complex had 0.87%ID in the brain and 1.02% ID in the heart at 2 min and it had a longer retention in brain (0.62%ID was maintained at 15 min postinection) but rapidly cleared from heart (0.33%ID postinjection). For the second complex, it showed very rapid blood clearance. The uptake of heart, lung and blood in mice at 2 min respectively were: 1.32%ID, 2.48%ID and 6.66%ID. These two complexes formation were 2rapid, simple and of high yield(91%). The processes were easy to kit formulation.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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