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  • 1 Institut für Nuklearchemie der Kernforschungsanlage Jülich GmbH D-5170 Jülich FRG
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Abstract  

The radioisotopes123I (T=13.3 h) and, potentially,211At(T=7.2 h) find increasing interest for radiopharmaceutical applications in diagnosis and therapy. They were produced via the122Te(α, 3n)13Xe(α+)13I and the209Bi(α, 2n)211At processes. Fast and efficient separations of carrier-free species obtained from target processing, as well as from classical or decay-induced synthesis were archieved by means of high-pressure ion-exchange and partition chromatography. Inorganic forms (X, XO 3 , At+) could be identified and separated on pretreated Aminex A 27 and A 7 resins, and biomolecules such as 5-halodeoxyuridines and-uracils on Aminex A 25 resins and Merckosorb Si 60 silica. The chromatographic methods can also be used for stability tests of radiopharmaceuticals in biochemical mixtures, notably physiological fluids.