Zinc in human prostate gland: Normal, hyperplastic and cancerous

V. Zaichick; T. Sviridova; S. Zaichick

doi:10.1007/bf02034434

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 217: Issue 2

Zinc in human prostate gland: Normal, hyperplastic and cancerous

Authors:

V. Zaichick

V. Zaichick Medical Radiological Research Centre 249020 Obninsk Kaluga Region Russia

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T. Sviridova

T. Sviridova Medical Radiological Research Centre 249020 Obninsk Kaluga Region Russia

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S. Zaichick

S. Zaichick Medical Radiological Research Centre 249020 Obninsk Kaluga Region Russia

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Pages:: 157–161

Online Publication Date:: 13 Aug 2005

Publication Date:: 17 Mar 1997

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02034434

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Abstract

Zinc concentration in a prostate gland is much higher than that in other human tissues. Data about zinc changes for different prostate diseases are limited and greatly contradictory. Zinc content was determined for biopsy and resected materials of transrectal puncture tissues from benign prostate hyperplasia (BPH) and prostate cancer. There were 109 patients (50 BPH and 59 cancer) available for the present study. Control group consisted of 37 intact glands of men died an unexpected death (accident, murder, acute cardiac insufficiency, etc.). All materials studied were divided into two parts. One of them was morphologically examined, while another one was subjected to zinc analysis by INAA. Zinc contents (M±SE) of normal, benign hyperplastic and cancerous prostate glands were found to be 1018±124, 1142±77, and 146±10 g/g dry tissue, respectively. It was shown that zinc assessments in the materials of transrectal puncture biopsy of indurated prostate sites can be used as an additional test for differential diagnostics of BPH and cancer. Accuracy, sensitivity and specificity of the test are 98±2%.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)