CPAA for studying biokinetics with stable isotopes: A preliminary investigation on zirconium metabolism in animals

M. Cantone; D. De Bartolo; A. Giussani; L. Garlaschelli; Ch. Hansen; P. Roth; E. Werner

doi:10.1007/bf02034456

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 217: Issue 2

CPAA for studying biokinetics with stable isotopes: A preliminary investigation on zirconium metabolism in animals

Authors:

M. Cantone

M. Cantone

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D. De Bartolo

D. De Bartolo

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A. Giussani

A. Giussani Università degli Studi di Milano Dipartimento di Fisica, Sezione di Fisica Medica via Celoria 16 1-20133 Milano Italy

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L. Garlaschelli

L. Garlaschelli Università degli Studi di Milano Dipartimento di Chimica Inorganica, Metallorganica e Analitica via Celoria 20 1-20133 Milano Italy

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Ch. Hansen

Ch. Hansen Klinikum der J. W. Goethe-Universität Bereich Rheumatologie, Med. Klinik III D-60590 Frankfurt am Main Germany

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P. Roth

P. Roth GSF-Forschungszentrum für Umwelt und Gesundheit Institut für Strahlenschutz D-85758 Oberschleißheim Germany

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E. Werner

E. Werner GSF-Forschungszentrum für Umwelt und Gesundheit Institut für Strahlenschutz D-85758 Oberschleißheim Germany

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Pages:: 279–282

Online Publication Date:: 13 Aug 2005

Publication Date:: 17 Mar 1997

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02034456

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Abstract

In order to estimate gut absorption by determining tracer concentration in plasma, a technique based on the administration of two stable isotopes of the same element was combined with proton activation analysis. The optimization for the determination of Zr isotopes in biological samples is presented together with the results of a preliminary study on Zr biokinetics in animals. (p,n) reactions on⁹⁰Zr and⁹⁶Zr resulted the most convenient. The obtained minimum detectable quantities are 3 and 2 ng/ml plasma, respectively, for⁹⁰Zr and⁹⁶Zr. Zr plasma clearance and Zr response to a simple oral test were studied separately in different subjects by using the natural Zr solution. The data analysis was performed measuring the concentration of⁹⁰Zr to obtain indication on the time behavior and fractional level of Zr appearance in plasma depending on the administration routes. Two rabbits were intravenously injected 50 g⁹⁰Zr and a third rabbit was orally given 2.5 mg of⁹⁰Zr. Concentration in plasma samples of intravenously and orally given Zr isotopes are reported, as a function of time after administration. The injected tracer concentration relative to the first two rabbits were fitted simultaneously to obtain clearance parameters. Zr intestinal absorption is evaluated to be less than 0.2%. The work confirms that proton activation is a powerful tool for biokinetic studies with stable isotopes.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)