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  • 1 University of Ghent Department of Radiopharmacy, Faculty of Pharmaceutical Sciences Harelbekestraat 72 9000 Ghent Belgium
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The synthesis of 7-bromo-5-[123I]-iodokynurenic acid is described. The tracer was prepared using a nucleophilic non-isotopic exchange reaction from the corresponding bromo derivative. Optimisation of the reaction parameters and HPLC purification were performed and the radiotracer was obtained in a chemical and radiochemical purity >95% and a specific activity of 235 Ci/mol.