Simple preparation of76Br,123I and211At labeled 5-halo-2′-deoxyuridine

J. Koziorowski; R. Weinreich

doi:10.1007/bf02040279

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 219: Issue 1

Simple preparation of⁷⁶Br,¹²³I and²¹¹At labeled 5-halo-2′-deoxyuridine

Authors:

J. Koziorowski

J. Koziorowski

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R. Weinreich

R. Weinreich Paul Scherrer Institute Institute for Medical Radiobiology CH-5232 Villigen PSI Switzerland

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Pages:: 127–128

Online Publication Date:: 14 Aug 2005

Publication Date:: 17 May 1997

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02040279

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Abstract

A fast and easy method for the preparation of radiolabeled 5-halo-2-deoxyuridine (halo=[⁷⁶Br], [¹²³I] and [²¹¹At]) is presented. Labeling is accomplished by oxidation of the halogenide with Iodogen for [¹²³I] and [²¹¹At], and Chloramine-T (CAT) for [⁷⁶Br] followed by halodestannylation of 5-trimethylstannyl-2-deoxyuridine (TMSUdR). The reaction takes 1 minute giving >90% yield for all three halogens.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)