Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 220: Issue 1
Preparation and isolation of a homogeneous125I-cortisol derivative
Authors: Sh. Menon 1 , G. Samuel 1 , and S. Balakrishnan 1
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  • 1 Bhabha Atomic Research Centre Isotope Division Trombay 400085 Bombay India
Pages:
21–26
Online Publication Date:
13 Aug 2005
Publication Date:
17 Jun 1997
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf02035341
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Abstract  

Tracer specificity plays an important role in the radioimmunoassay (RIA) of steroid homones. In this paper, we describe the preparation and purification of125I-labeled cortisol derivative with a carboxymethyloxime-histamine bridge. The investigation on the method of purification showed that HPLC could be adopted for the routine preparation of a pure, homogeneous tracer. The retention time observed in HPLC for125I-histamine-CMO-cortisol conjugate could be used as an index for qualitative and quantitative assessments.

Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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