153Sm metallic-hydroxide macroaggregates: An improved preparation for radiation synovectomy

G. Ferro-Flores; L. García-Salinas; M. Pedraza-López; M. González-Zavala; J. Tendilla; M. López-Gómez

doi:10.1007/bf02034253

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 222: Issue 1-2

¹⁵³Sm metallic-hydroxide macroaggregates: An improved preparation for radiation synovectomy

Authors:

G. Ferro-Flores

G. Ferro-Flores Instituto Nacional de Investigaciones Nucleares Department of Radioactive Materials Km. 36.5 Carretera México-Toluca C. P. 52045 Salazar Edo. de México

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L. García-Salinas

L. García-Salinas Instituto Nacional de Investigaciones Nucleares Department of Radioactive Materials Km. 36.5 Carretera México-Toluca C. P. 52045 Salazar Edo. de México

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M. Pedraza-López

M. Pedraza-López Instituto Nacional de Investigaciones Nucleares Department of Radioactive Materials Km. 36.5 Carretera México-Toluca C. P. 52045 Salazar Edo. de México

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M. González-Zavala

M. González-Zavala Instituto Nacional de Pediatría Department of Nuclear Medicine Insurgentes 3700-C Colonia Cuicuilco Insurgentes C. P. 04330 México D. F. México

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J. Tendilla

J. Tendilla Instituto Nacional de Investigaciones Nucleares Department of Radioactive Materials Km. 36.5 Carretera México-Toluca C. P. 52045 Salazar Edo. de México

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M. López-Gómez

M. López-Gómez Instituto Nacional de Investigaciones Nucleares Department of Radioactive Materials Km. 36.5 Carretera México-Toluca C. P. 52045 Salazar Edo. de México

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Pages:: 93–97

Online Publication Date:: 14 Aug 2005

Publication Date:: 01 Aug 1997

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02034253

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Abstract

A new type of preparation employing¹⁵³Sm metallic-hydroxide macroaggregates (¹⁵³Sm-MHM) for radiation synovectomy was developed. The radiopharmaceutical was prepared by reacting the aqueous solution of¹⁵³SmCl₃ with sodium borohydride solution in 0.5N NaOH. Microscopic analysis showed that¹⁵³Sm-MHM mean particle size was 4 m (range 1–15 m) avoiding the formation of fine particles (<1 m) which were¹⁵³Sm-hydroxide macroaggregates preparations (¹⁵³Sm-HM). Also, suspension properties as sedimentation rate, were better for¹⁵³Sm-MHM than for¹⁵³Sm-hydroxyapatite and¹⁵³Sm-HM. Biological studies in normal rabbits demonstrated high retention into de Knee joint space even at 48 h after administration of¹⁵³Sm-MHM (>99%).

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)