Authors:
Jiunn-Liang Lin Yuampei Institute of Medical Technology Department of Radiological-Technology 306, Yuanpei St. Hsinchu City Taiwan, Republic of China

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Ai-Yih Wang Yuampei Institute of Medical Technology Department of Radiological-Technology 306, Yuanpei St. Hsinchu City Taiwan, Republic of China

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Jiunn-Guang Lo National Tsing Hua University Institute of Nuclear Science Taiwan, Republic of China

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Ren-Shyan Liu Veterans General Hospital-Taipei Taiwan, Republic of China

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Abstract  

Lipiodol has excellent retainable ability in hepatoma cells. This agent can be labeled with radioisotope (131I) and mixed with tissue adhesive (Histoacryl), and then alttached on the lesion of liver by intrahepatic arterial administration. In this study, we attempt to obtain the optimal ratio of Lipiodol to Histoacryl and evaluate the consolidation of blood in vitro and toxicity and biodistribution in vivo. The ratio of131I Lipiodol/Histoacryl mixture (L/H), concentration of heparin and flow rate of blood are varied by simulating the installation of bloodstream to test the time of consolidation. In addition, the optimal ratios of the L/H mixtures are assessed in vitro in heparinized human blood. According to those results, Lipiodol and Histoacryl mixed with 1∶1 or 2∶1 ratio have an ideal time of 13 to 15 seconds in vitro; in addition, 1.2∶1 ratio is an optimal ratio in the biodistribution study. Interestingly, heparin and acetic acid does not alter the consolidation time, in addition, no variation occurs when varying the flow rate of blood. The consolidation of L/H mixture with blood is incubated in the 37°C, normal saline bath for 24 hours. No dissociation of free131I is found. The optimal mixture is also injected into the hepatic artery of the Sprague-Dawley rats carrying for 24 hours. No dissociation of free131I is found. The optimal mixture is also injected into the hepatic artery of the Sprague-Dawley rats carrying hepatocellular carcinoma (NIS1 cell line). Radioactive consolidate is well confined in the tumor without evidence of leakage of the mixture to the lung or distribution of free131I in the thyroid. In conclusion, this mixture has the merits of both irradiation and embolization of the tumor. The131I Lipiodol/Histoacryl mixture (1.2∶1) is a promising alternative for intrahepatic arterial administration to treat hepatic tumors. Histoacryl can confine the131I and, also, embolize the tumor vessels.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)