Authors:
F. Wang China Institute of Atomic Energy P. O. Box 275(58) 102413 Beijing P. R. China

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H. Fan China Institute of Atomic Energy P. O. Box 275(58) 102413 Beijing P. R. China

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D. Chen China Institute of Atomic Energy P. O. Box 275(58) 102413 Beijing P. R. China

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H. Bai China Institute of Atomic Energy P. O. Box 275(58) 102413 Beijing P. R. China

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Z. Chen China Institute of Atomic Energy P. O. Box 275(58) 102413 Beijing P. R. China

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L. Xiao China Institute of Atomic Energy P. O. Box 275(58) 102413 Beijing P. R. China

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Abstract  

Radiolabeled somatostatin analogue is a useful ligand for scintigraphic imaging of somatostatin receptor-bearing tumors. In this study, we investigated the effects of different radiolabeling conditions on labeling yield and ratio between mono-iodinated and di-iodinated125I-Tyr3-octreotide by HPLC analysis. In vitro and in vivo stabilities of125I-Tyr3-octreotide and111In-DTPA-D-Phe1-octreotide were also determined. Both radiolabeled compounds were relatively stable in vitro, but were decomposed to free125I− and111In-DTPA in vivo, respectively.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)