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  • 1 China Institute of Atomic Energy P. O. Box 275(58) 102413 Beijing P. R. China
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Abstract  

Radiolabeled somatostatin analogue is a useful ligand for scintigraphic imaging of somatostatin receptor-bearing tumors. In this study, we investigated the effects of different radiolabeling conditions on labeling yield and ratio between mono-iodinated and di-iodinated125I-Tyr3-octreotide by HPLC analysis. In vitro and in vivo stabilities of125I-Tyr3-octreotide and111In-DTPA-D-Phe1-octreotide were also determined. Both radiolabeled compounds were relatively stable in vitro, but were decomposed to free125I− and111In-DTPA in vivo, respectively.