Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 236: Issue 1-2
Longitudinal study of iodine in toenails following IV administration of an iodine-containing contrast agent
Authors:
V. Spate University of Missouri Research Reactor Center 65211 Columbia MO USA

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J. Morris University of Missouri Research Reactor Center 65211 Columbia MO USA

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T. Nichols University of Missouri Research Reactor Center 65211 Columbia MO USA

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C. Baskett University of Missouri Research Reactor Center 65211 Columbia MO USA

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M. Mason University of Missouri Research Reactor Center 65211 Columbia MO USA

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T. Horsman University of Missouri Research Reactor Center 65211 Columbia MO USA

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P. Horn-Ross Northern California Cancer Center 94587 Union City CA USA

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A. Shiau Northern California Cancer Center 94587 Union City CA USA

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I. McDougall Stanford University School of Medicine, Division of Nuclear Medicine 94305 Stanford CA USA

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Pages:
71–77
Online Publication Date:
12 Apr 2006
Publication Date:
17 Oct 1998
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf02386320
Restricted access

Abstract  

The literature on the relationship between diet and thyroid cancer (TC) risk and the higher incidence of TC among Asian immigrants to the US compared to second and third generation subgroups has prompted epidemiologists to hypothesize that increased levels of iodine consumption may be associated with TC risk, particularly among persons with a history of clinical or subclinical thyroid dysfunction. At the University of Missouri Research Reactor (MURR), we have applied epiboron neutron activation analysis to investigate human nails as a dietary monitor for iodine. Preliminary studies have indicated a positive correlation between dietary iodine intake and the concentration of iodine in toenails. However, these studies are confounded by high iodine levels (up to 30 ppm) in approximately 5% of the nails studied. We hypothesize that, in the subjects we have studied, the high iodine levels may be due to iodine-containing medications, in particular contrast-agents containing iopamidol. This paper will report on longitudinal studies using contrast agent subjects who were followed-up for almost two years compared to a longitudinal control and a population mean. Based on this study, we suggest that iodine-containing contrast agents contaminate nail samples via non-specific binding in the short term followed by incorporation in the nail as a result of absorption.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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