Synthesis of astatine-tagged methylene blue, a compound for fighting micrometastases and individual cells of melanoma

Yu. Norseev

doi:10.1007/bf02386681

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 237: Issue 1-2

Synthesis of astatine-tagged methylene blue, a compound for fighting micrometastases and individual cells of melanoma

Author:

Yu. Norseev

Yu. Norseev Joint Institute for Nuclear Research Laboratory of Nuclear Problems Dubna Russia

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Pages:: 155–158

Online Publication Date:: 12 Apr 2006

Publication Date:: 17 Nov 1998

Article Category:: Research Article

DOI:: https://doi.org/10.1007/bf02386681

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Abstract

Investigation on electrophilic attaching of astatine-211 to methylene blue is carried out. Conditions for transferring astatine to a chemically active electrophilic form were found. A method for the production of astatine-211-tagged methylene blue has been developed. The resulting radiopharmaceutical preparation is free of the nonisotopic iodine carrier. The chromatographic method of purifying simultaneously the product by anion-exchange resin QAE-Sephades A-25 allows it to pass into a 0.9% solution of sodium chloride (physiological salt solution). The method provides the radiochemical yield of astatine-211-tagged methylene blue as large as 68±6%.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)