Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 240: Issue 1
New99mTc-diiodine substituted IDA derivative (DIIODIDA) for hepatobiliary imaging
Authors:
M. JovanovićVinča Institute of Nuclear Sciences Laboratory for Radioisotopes P. O. Box 522 11001 Belgrade Yugoslavia

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J. BrborićUniversity of Belgrade Faculty of Pharmacy Yugoslavia

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S. VladimirovUniversity of Belgrade Faculty of Pharmacy Yugoslavia

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B. ZmbovaVinča Institute of Nuclear Sciences Laboratory for Radioisotopes P. O. Box 522 11001 Belgrade Yugoslavia

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LJ. VuksanovićVinča Institute of Nuclear Sciences Laboratory for Radioisotopes P. O. Box 522 11001 Belgrade Yugoslavia

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D. Živanov-StakićUniversity of Belgrade Faculty of Pharmacy Yugoslavia

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V. ObradovićInstitute of Nuclear Medicine Clinical Centre of Serbia Belgrade Yugoslavia

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Pages:
321–324
Online Publication Date:
10 Apr 2006
Publication Date:
17 Apr 1999
Article Category:
Research Article
DOI:
https://doi.org/10.1007/bf02349171
Restricted access

Abstract  

A new diiodine substituted IDA derivative, 2,4-diiodine-6-methyl IDA (DIIODIDA) was synthesized and labeled with99mTc. It was established that99mTc-DIIODIDA had high radiochemical purity. Biodistribution and influence of bilirubin on99mTc-DIIODIDA biokinetics has been studied in rats and compared to the corresponding results for99mTc-SOLCOIODIDA. Related to99mTc-SOLCOIODIDA,99mTc-DIIODIDA has much better biliary exretion (55.18 versus 43.63%). No change of99mTc-DIIODIDA biokinetics, under influence of bilirubin was noticed. Biliary excretion of99mTc-SOLCOIODIDA has been reduced for about 60%. The protein binding of99mTc-DIIODIDA and99mTc-SOLCOIODIDA were also determined, using in vitro method of precipitation. These results showed that99mTc-DIIODIDA hepatobiliary imaging agent is superior to the presently used99mTc-monoiodine IDA derivatives.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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