The radiochemical purity of MDP and HEDP has been determined by means of gel chromatography on Sephadex and thin layer chromatography
on plastic foil silica gel. The comparison of the two radiopharmaceuticals shows equal level of complex formation with99mTc. The biodistribution demonstrated that the application of HEDP allows earlier scanning than MDP. MDP and HEDP show equal
effectivity during the clinical investigations. There is no significant difference in the radiochemical purity within six
hours after the reconstitution of the freeze-dried kits. HEDP kit demonstrates shorter period of accumulation and equivalent
complex formation levels, so it can be used in routine nuclear medicine diagnostics together with MDP kit.