Authors:
A. Perera Center for Clinical Research Havana Cuba

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C. Perez Institute for Cardiology and Cardiovascular Surgery Havana Cuba

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M. Torres Institute for Cardiology and Cardiovascular Surgery Havana Cuba

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A. Henandez Center for Clinical Research Havana Cuba

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F. Heres Institute for Cardiology and Cardiovascular Surgery Havana Cuba

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T. Moreira National Center for Scientific Researches Havana Cuba

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A. Gutierrez National Center for Scientific Researches Havana Cuba

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A. Gigato National Center for Scientific Researches Havana Cuba

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I. Hernandez Isotopes Center Havana Cuba

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L. Alberti Isotopes Center Havana Cuba

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O. Marrero Institute for Cardiology and Cardiovascular Surgery Havana Cuba

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L. Martinez National Institute for Oncology and Radiobiology Havana Cuba

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J. Sanfiz National Institute for Oncology and Radiobiology Havana Cuba

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E. Sanchez National Institute for Oncology and Radiobiology Havana Cuba

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J. Rodriguez National Institute for Oncology and Radiobiology Havana Cuba

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L. Marrero Orthopedic Hospital “Frank Pais” Havana Cuba

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G. Parra Isotopes Center Havana Cuba

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Abstract  

The aim of this work was to obtain a freeze-dried kit for direct99mTc-labeling of human polyclonal IgG. The labeling procedure was carried out by Schwarz's method. The best yields of99mTc-IgG were obtained by using sodium pyrophosphate decahydrate as a weak chelating agent. Performed tests showed the stability of the radiopharmaceutical up to 24 hours. Plasma clearance in rats was fitted to a biexponential curve withT1/2α=(0.1 ±0.9) h andT1/2β=(10±3) h. The organs with higher uptake of radiopharmaceutical were lung, kidneys and blood. In a rabbit model the abscess target/background ratio was 3–6 according to time of the scintigraphic images. Thirty patients with musculoskeletal infection were studied. Twenty-one lesions were detected and confirmed by culture/biopsy.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)