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M. Suzarte Center of Molecular Immunology P.O.Box 16040 11600 Havana Cuba

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N. Rodríguez Center for Medical-Surgical Researches (CIMEQ) Calle 216 y 13 11600 Havana Cuba

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J. Oliva National Institute of Oncology and Radiobiology 29 y E, Vedado Havana Cuba

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N. Iznaga Center of Molecular Immunology P.O.Box 16040 11600 Havana Cuba

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A. Perera Center of Clinical Researches Calle 45 y 34, No. 4501, Rpto Kohly Havana Cuba

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A. Morales Center of Molecular Immunology P.O.Box 16040 11600 Havana Cuba

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N. Gonzalez Center for Medical-Surgical Researches (CIMEQ) Calle 216 y 13 11600 Havana Cuba

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O. Torres Center of Molecular Immunology P.O.Box 16040 11600 Havana Cuba

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T. Rodríguez Center of Molecular Immunology P.O.Box 16040 11600 Havana Cuba

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Abstract  

Monoclonal antibody ior egf/r3 is a IgG2a, recognizes the epidermal growth factor receptor. The aim of the present work was to evaluate the diagnostic efficacy of the99mTc-labeled ior egf/r3 for the detection of epithelial tumors, its metastasis and its recurrences. The sensitivity by organs was: brain 100%, diegestive tract 90%, head and neck 89%, lung 84% and breast 79%. The overall sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the immunoscintigraphic imaging were 84.1%, 100%, 86.5%, 100% and 52.4%, respectively. Immunoscintigraphy with99mTc-ior egf/r3 is useful for the diagnosis and follow-up of epithelial tumors.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)