Authors:
J. Slabbert National Accelerator Centre P.O.Box 72 7131 Faure South Africa

Search for other papers by J. Slabbert in
Current site
Google Scholar
PubMed
Close
,
J. Langenhoven National Accelerator Centre P.O.Box 72 7131 Faure South Africa

Search for other papers by J. Langenhoven in
Current site
Google Scholar
PubMed
Close
, and
B. Smit National Accelerator Centre P.O.Box 72 7131 Faure South Africa

Search for other papers by B. Smit in
Current site
Google Scholar
PubMed
Close
Restricted access

Abstract  

4-Iodoantipyrine was synthesised from phenazone, labeled with123I and administered to cells in culture. 4-[123I]iodoantipyrine carries the radionuclide across the cell membrane allowing one to study the biological effects of the very short ranged Auger electrons emitted by this isotope. The formulation used to prepare this compound proves to be free of reagents that may have an adverse effect on the mitotic activity of cells in culture. By observing micronuclei frequencies in human lymphocytes and CHO-K1 cells the high-LET characteristics of Auger electrons could be demonstrated. Compared to extracellular disintegrations from [123I]NaI and123I-human serum albumin, a substantial reduction in the variation in radiosensitivity of these cell types was noted when treated with 4-[123I] iodoantipyrine.

  • Collapse
  • Expand

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)