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  • 1 German Cancer Research Centre, Department of Radiochemistry im Neuenheimer Feld 280 D-69120 Heidelberg Germany
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Abstract  

The β-emitting isotope142gPr (T1/2=19.13 h, E(β)max=2.16 MeV) is a suitable radionuclide for internal radiotherapy with tumor-seeking biomolecules.142gPr can be prepared from natural141Pr by irradiation with thermal neutrons. We investigated the Szilard-Chalmers reaction in well-defined complexes with various ligands and a salt in order to measure the enrichment factors and extracted yields to find a route for the production142gPr of high specific radioactivity, ionic142gPr3+ was separated from the complex by cation exchange and high performance liquid chromatography (HPLC).