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  • 1 Institut für Bioanorganische und Radiopharmazeutische Chemie Forschungszentrum Rossendorf P.O. Box 51 01 19 D-01314 Dresden Germany
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The coupling of Re- and99mTc-MAG3 complexes with amines and nucleobases was carried out with good yields using O-(benzotriazol-1-yl-)-N,N,N',N'-tetramethyl-uronium-tetrafluoroborate (TBTU), and base in polar aprotic solvents (NMP, DMF, DMSO). The one step reaction followed by simple gel chromatography makes the method well appropriate for preparations at the low no-carrier-added level of technetium-99m.