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  • 1 Nippon Telegraph and Telephone Corporation, Tokai, Ibaraki NTT Opto-electronics Laboratories 319-1193 Japan
  • 2 High Energy Accelerator Research Organization, Midori-cho, Tanashi Radiation Science Center 188-8501 Tokyo Japan
  • 3 Tohoku University Laboratory of Nuclear Science, Faculty of Science 1-2-1, Mikamine 982-0826 Sendai Japan
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We studied the production of nine typical organic analytical reagents labeled with11C,13N and18F by irradiation with charged particles and bremsstrahlung and the purification of labeled compounds with HPLC and sublimation. As a result, we found that six reagents, α-naphthol, β-naphthol, quinoline, α-nitroso-β-naphthol, 8-hydroxyquinoline, and 1,10-phenanthroline H2O could be labeled with11C by bombarding a mixture of each reagent and boron with protons. More than 10% of the11C was successfully exchanged with carbon atoms in the original reagents. We also found that sublimation is useful for purifying 8-hydroxyquinoline labeled with11C. The extraction property of11C-labeled 8-hydroxyquinoline between water and chloroform could be easily monitored by radioactivity measurement.