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  • 1 Nippon Telegraph and Telephone Corporation, Tokai, Ibaraki NTT Opto-electronics Laboratories 319-1193 Japan
  • 2 High Energy Accelerator Research Organization, Midori-cho, Tanashi Radiation Science Center 188-8501 Tokyo Japan
  • 3 Tohoku University Laboratory of Nuclear Science, Faculty of Science 1-2-1, Mikamine 982-0826 Sendai Japan
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Abstract  

We studied the production of nine typical organic analytical reagents labeled with11C,13N and18F by irradiation with charged particles and bremsstrahlung and the purification of labeled compounds with HPLC and sublimation. As a result, we found that six reagents, α-naphthol, β-naphthol, quinoline, α-nitroso-β-naphthol, 8-hydroxyquinoline, and 1,10-phenanthroline H2O could be labeled with11C by bombarding a mixture of each reagent and boron with protons. More than 10% of the11C was successfully exchanged with carbon atoms in the original reagents. We also found that sublimation is useful for purifying 8-hydroxyquinoline labeled with11C. The extraction property of11C-labeled 8-hydroxyquinoline between water and chloroform could be easily monitored by radioactivity measurement.