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  • 1 University Medical School of Debrecen PET Centre Nagyerdei krt 98 H-4012 Debrecen Hungary
  • 2 University Medical School of Debrecen Department of Pharmacology Nagyerdei krt 98 H-4012 Debrecen Hungary
  • 3 Institute of Nuclear Research of the Hungarian Academy of Science Bem tér 18/C H-4026 Debrecen Hungary
  • 4 Institute of Isotopes Co. Ltd. P.O. Box 851 H-1525 Budapest Hungary
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Abstract  

[11C]-labeled form of ten A2a adenosine receptor specific 8-styryl-7-methyl-xanthine derivatives ([11C]-caffeines) were synthesised by N-methylation of the corresponding 8-styryl-xanthine derivatives using [11C]-methyl iodide in optimized reaction conditions. The results show that the [11C]-methylations take place with excellent radiochemical yields (35–93%), and can be utilised easily in online preparations. These labeled ligands may facilitate the positron emission tomographic (PET) investigation of adenosine A2a receptors.