Enzymatic Synthesis of [3-14C]Cinnamic Acid

J. Bukowski; J. Szul; R. Kański; M. Kańska

doi:10.1023/a:1010649715196

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 243: Issue 3

Enzymatic Synthesis of [3-14C]Cinnamic Acid

Authors:

J. Bukowski

J. Bukowski University of Warsaw Department of Chemistry ul. Pasteur 1 Warsaw Poland

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J. Szul

J. Szul University of Warsaw Department of Chemistry ul. Pasteur 1 Warsaw Poland

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R. Kański

R. Kański University of Warsaw Department of Chemistry ul. Pasteur 1 Warsaw Poland

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M. Kańska

M. Kańska University of Warsaw Department of Chemistry ul. Pasteur 1 Warsaw Poland

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Pages:: 635–638

Online Publication Date:: 02 Nov 2004

Publication Date:: 17 Mar 2000

Article Category:: Research Article

DOI:: https://doi.org/10.1023/a:1010649715196

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Abstract

Convenient and efficient route of the synthesis of [3-¹⁴C] cinnamic acid is reported. [1-¹⁴C]Benzoic acid, prepared by carbonation of Grignard reagent with [¹⁴C]carbon dioxide, was reduced to [1-¹⁴C]benzyl alcohol. In the enzymatic step this alcohol was selectively oxidised to [1-¹⁴C]benzaldehyde using enzyme YADH (Ec. 1.1.1.1) and immediately condensed with malonic acid. This combined chemical and enzymatic approach allows to obtain [3-¹⁴C]cinnamic acid with radiochemical yield higher than 50% in respect to the starting alcohol.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)