Authors:
Ning LiuSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Jiannan JinSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Shuyuan ZhangSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Shangwu MoSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Yuanyou YangSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Juan WangSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Maolun ZhouSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Abstract  

An antigastric cancer monoclonal antibody, 3H11 and its Fab fragment, were labeled with #-emitter 211At using p-[211At] astatobenzoic acid (PAtBA) intermediate. The astatinated antibodies had conspicuous cytotoxic effect on human gastric cancer cell M85 in vitro. Tissue distribution of the astatinated antibodies were investigated in nude mice with subcutaneous tumor xenografts by i.v. injection. The astatinated Fab fragment was better suitable for 7.2-hour half life of 211At, since its tumor uptake remained higher (9.48–8.42 I.D%/g) than the astatinated intact antibody (~4.0 I.D%/g) from 3 to 14-hour post injection. However, the undesired high 211At uptake of the astatinated antibodies in some normal tissues, such as stomach, kidney and lung, suggested that the 211At labeled antibodies should be further explored.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)