Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 247: Issue 1
211At labeling of a monoclonal antibody and its Fab fragment: Cytotoxicity on human gastric cancer cells and biodistribution in nude mice with tumor xenografts
Authors:
Ning LiuSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Jiannan JinSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Shuyuan ZhangSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Shangwu MoSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Yuanyou YangSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Juan WangSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Maolun ZhouSichuan University Key Laboratory of Radiation Physics and Technology of Education Ministry of China, Institute of Nuclear Science and Technology Chengdu 610064 P. R. China

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Pages:
129–133
Online Publication Date:
29 Oct 2004
Publication Date:
17 Jan 2001
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1006727401721
Restricted access

Abstract  

An antigastric cancer monoclonal antibody, 3H11 and its Fab fragment, were labeled with #-emitter 211At using p-[211At] astatobenzoic acid (PAtBA) intermediate. The astatinated antibodies had conspicuous cytotoxic effect on human gastric cancer cell M85 in vitro. Tissue distribution of the astatinated antibodies were investigated in nude mice with subcutaneous tumor xenografts by i.v. injection. The astatinated Fab fragment was better suitable for 7.2-hour half life of 211At, since its tumor uptake remained higher (9.48–8.42 I.D%/g) than the astatinated intact antibody (~4.0 I.D%/g) from 3 to 14-hour post injection. However, the undesired high 211At uptake of the astatinated antibodies in some normal tissues, such as stomach, kidney and lung, suggested that the 211At labeled antibodies should be further explored.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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