Feasibility study for the production of 32 P-labeled diphosphonic acids by neutron irradiation and radiochemical separation

K. Volkers

doi:10.1023/a:1013269125267

Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 249: Issue 2

Feasibility study for the production of 32 P-labeled diphosphonic acids by neutron irradiation and radiochemical separation

Author:

K. Volkers

K. Volkers Delft University of Technology Department of Radiochemistry, Interfaculty Reactor Institute Mekelweg 15 2629 JB Delft The Netherlands

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Pages:: 279–282

Online Publication Date:: 29 Oct 2004

Publication Date:: 17 Aug 2001

Article Category:: Research Article

DOI:: https://doi.org/10.1023/a:1013269125267

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Abstract

Two simple diphosphonates, CH₆P₂ O₆(MDP) and C₂ H₈ P₂ O₇ (HEDP),have been irradiated with neutrons to produce the corresponding ³²P-labeled compounds. After irradiation for 0.5–5 hours in a thermalneutron flux of 4.2 . 10¹⁶ n . m ^—2 s^—1 the irradiated compounds were dissolved and fractionated using a SephadexG10 column. The separated fractions were identified using planar paper chromatographyand autoradiography. The labeling yield was ca 35% for each of the compounds,and the specific activity attainable ranged up to 4.8 GBq . mol ^—1 . For practical applications, the labeled diphosphonates have to bepurified further.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)