Use of bomb pulse 14C to age senile plaques and neurofibrillary tangles in the Alzheimer's disease brain

W. Markesbery

doi:10.1023/a:1013299426601

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 249: Issue 2

Use of bomb pulse 14C to age senile plaques and neurofibrillary tangles in the Alzheimer's disease brain

Author:

W. Markesbery

W. Markesbery University of Kentucky Departments of Neurology and Pathology Lexington KY 40506 USA

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Pages:: 443–447

Online Publication Date:: 29 Oct 2004

Publication Date:: 17 Aug 2001

Article Category:: Research Article

DOI:: https://doi.org/10.1023/a:1013299426601

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Abstract

The time course and defining factors involved in the formation of neurofibrillarytangles (NFT) and senile plaques (SP) in Alzheimer's disease (AD) brainare unknown. Above ground nuclear weapons tests led to significantly increasedlevels of ¹⁴C in the carbon cycle. Because SP and NFT are relativelyresistant to degradation, the ¹⁴C levels in SP and NFT should reflecttheir year of formation. Through the use of accelerator mass spectrometry(AMS) and the measurement of ¹⁴C levels, we have determined theaverage age of formation of isolated SP and NFT fractions of 6 AD subjects.While a heterogeneous process of formation is indicated, NFT pre-date SP inthe majority of cases. In addition, it is clear that NFT and SP have a muchslower carbon turnover rate than normal brain tissue.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)