Combined biochemical separation and INAA for the determination of iron and other metals in Neuromelanin of human brain Substantia Nigra

M. Gallorini

doi:10.1023/a:1013251510671

Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 249: Issue 2

Combined biochemical separation and INAA for the determination of iron and other metals in Neuromelanin of human brain Substantia Nigra

Author:

M. Gallorini

M. Gallorini Center of Radiochemistry and Activation Analysis-CNR Via Taramelli, 12 27100 Pavia Italy

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Pages:: 449–454

Online Publication Date:: 29 Oct 2004

Publication Date:: 17 Aug 2001

Article Category:: Research Article

DOI:: https://doi.org/10.1023/a:1013251510671

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Abstract

In Parkinson disease Fe and other metals increase in Substantia Nigra(SN) and other basal nuclei. Since Fe can generate citotoxic free radicals,Neuromelanin (NM) could play an important protective role in neurons. In thiswork an original procedure for separation of NM, preparation of samples andanalysis is presented. The determination of SN and its NM elemental contentwas carried out by instrumental neutron activation analysis. Several actionswere taken to reduce the metal contaminations: use of high purity reagents,dissection of tissues with titanium coated tools and adequate processing ofsamples.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)