Synthesis of 99m TcN(IPDTC)2 and its biodistribution in mice

Xuebin Wang

doi:10.1023/a:1013242130661

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 249: Issue 3

Synthesis of 99m TcN(IPDTC)2 and its biodistribution in mice

Author:

Xuebin Wang

Xuebin Wang Beijing Normal University Department of Chemistry Beijing 100875 P. R. China

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Pages:: 573–576

Online Publication Date:: 29 Oct 2004

Publication Date:: 17 Sep 2001

Article Category:: Research Article

DOI:: https://doi.org/10.1023/a:1013242130661

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Abstract

In order to seek a new class of brain perfusion imaging agent containing[ ^99m TcN]²+ core, the bis(N-isopropyl dithiocarbamato)nitrido technetium-99m complex [ ^99m TcN(IPDTC)₂ ] (IPDTC:N-isopropyldithiocarbamato) has been synthesized through a simple and efficient method,which can be utilized for the preparation of a radiopharmaceutical througha lyophilized formulation. The radiochemical purity of the complex was over90% determined by thin layer chromatography. No decomposition of the complexwas observed at room temperature over a period of 12 hours. Its partitioncoefficient indicated that it was a good lipophilic complex. Biodistributionin mice demonstrated that the complex was significantly retained into thebrain. The brain uptake (ID%/g) was 3.90, 2.67 and 1.54 and the brain/bloodratios were 1.26, 1.06 and 0.85 at 5, 30 and 60-minute post-injection, respectively.The results showed that the complex may lead to a further development of theradiopharmaceutical as a brain perfusion tracer.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)