A novel extractant, N,N-dilauroylpiperazine (DLPEZ), was synthesized for the first time. The extraction of uranium(VI) with the novel extractant in carbon tetrachloride from aqueous nitric acid media has been studied. The dependence of extraction distribution ratio on the concentration of aqueous nitric acid, extractant, salting-out agent and temperature was investigated and the enthalpy of the extraction was determined.