Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 251: Issue 1
Synthesis and labeling of 5'-O-(4,4'-dimethoxytrityl)-2,3'-anhydr othymidine for [18F]FLT preparation
Authors:
A. Blocher PET-Zentrum, Universitätsklinikum Tübingen Sektion Radiopharmazie Röntgenweg 15 72076 Tübingen Germany

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M. Kuntzsch PET-Zentrum, Universitätsklinikum Tübingen Sektion Radiopharmazie Röntgenweg 15 72076 Tübingen Germany

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R. Wei PET-Zentrum, Universitätsklinikum Tübingen Sektion Radiopharmazie Röntgenweg 15 72076 Tübingen Germany

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H.-J. Machulla PET-Zentrum, Universitätsklinikum Tübingen Sektion Radiopharmazie Röntgenweg 15 72076 Tübingen Germany

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Pages:
55–58
Online Publication Date:
01 Nov 2004
Publication Date:
17 Jan 2002
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1015042227131
Restricted access

Abstract  

For in vivo measurement of DNA synthesis in the patient"s tumour 3"-[18F]fluoro-3"-deoxythymidine (FLT) has been shown to be very promising. As a new labeling precursor 5"-O-(4,4"-dimethoxytrityl)-2,3"-anhydrothymidine (DMTThy) was chosen and an organic synthesis was developed including NMR and MS data for characterisation. The 18F-labeling of DMTThy can be performed within 30 minutes in radiochemical yields of almost 20% when using polar solvents such as DMF or DMSO and a temperature of 160 °C. Hydrolysis is completed with 1N HCl at 50 °C within 10 minutes without losses.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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